The first of a series of articles will be published this week inPediatrics, theJournal of Infectious DiseasesandThe Pediatrics.
“It’s time for a change”:
Pediatricians are concerned about the development of antibiotic resistance in certain pathogens that could arise from the use of bactrim.
In the last few years, a number of studies have been conducted to evaluate the efficacy of various oral antibiotics in the treatment of chronic obstructive pulmonary disease (COPD). These studies have been led by investigators in thePediatrics Respiratory and Gastroenterologyand have found that bactrim significantly reduced mortality in patients with COPD. A recent clinical trial in the US showed that bactrim reduced mortality in COPD patients with acute exacerbations of chronic obstructive pulmonary disease (COPD-AILD).
This study, which was a multicenter trial involving more than 6,000 children, revealed that bactrim reduced mortality in patients with COPD who had been treated with inhaled corticosteroids (ICS). Bactrim was well tolerated and did not cause exacerbations.
In a study of children and adolescents in a large trial of 612 children and adolescents with chronic bronchitis, investigators found that bactrim significantly reduced the rate of inhaled corticosteroid-induced exacerbations in patients with COPD and an ICS regimen. However, the study did not find that bactrim caused bronchospasm, a sign of inflammation of the airway that may have an effect on the treatment of COPD.
“The potential benefits”:
It was not until the first week of bactrim that investigators began to explore the possibility of antibiotic resistance of the bacteria.
The study authors concluded that “the potential benefits of bactrim outweigh its risks in the treatment of COPD”.
“I don’t think it’s a bad idea, especially when the benefits are so great that antibiotics can cause a lot of side effects. I hope it goes away in a few days”
The study authors concluded that they do not recommend any antibiotic treatment for COPD, but they do recommend “the use of bactrim in patients who cannot tolerate or do not tolerate oral antibiotics.”
“I don’t believe we can stop it from happening”:
In their review of the research, Dr. Susan L. Brown and colleagues concluded that “bactrim has not been shown to have significant antibiotic-associated adverse effects in COPD patients” and that “the potential benefits outweigh the risks when the potential benefits are not as great as they may be”.
“I would not recommend this drug for patients with COPD, even if there is a high risk of exacerbation”:
According to Brown and colleagues, “there is no evidence to suggest that bactrim may reduce mortality in patients with COPD”.
The authors of the study concluded that “the potential benefits of antibiotic therapy in COPD patients are unlikely to outweigh the risks when the benefits are not as great as they may be”.
“What is a good thing to do:
The benefits of bactrim outweigh the risks in patients with COPD who are not able to tolerate oral antibiotics”.
The study authors concluded that they do not recommend any antibiotic treatment for patients with COPD, but they do recommend “the use of bactrim in patients who cannot tolerate or do not tolerate oral antibiotics”.
“The potential benefits outweigh the risks in patients with COPD who are not able to tolerate or do not tolerate oral antibiotics”:
If you have any questions about BACTRIM DS use, please talk to your doctor.
In the US, for the first time, a new prescription is now available for BACTRIM DS. Please visit for more details.
To ensure that your BACTRIM DS is safe for you to use, read the instructions on your medicine label carefully.
Read each leaflet carefully before you start using this medicine. You will be asked to tell the person or medicines they are using to do so. If you need help remembering to take your medicine regularly, you may find that the information in this leaflet will help.
This leaflet provides general information about using BACTRIM DS. It also includes information about other uses, precautions, and potential side effects.
BACTRIM DS is a medicine for treating certain bacterial infections.
BACTRIM DS belongs to a group of medicines called ‘antibiotics’. BACTRIM DS works by killing bacteria and fighting infection.
BACTRIM DS may be taken with or without food. However, you should take special care if you take it with food or when you are sick (vomiting).
It is important not to drink alcohol while using BACTRIM DS.
Take this medicine exactly as your doctor has told you. The usual dose is one tablet with the amount of BACTRIM DS that is sufficient for you to treat your infection.
Take BACTRIM DS with a meal or with a small glass of water, preferably on an empty stomach.
Swallow BACTRIM DS with a full glass of water. Do not crush, chew or break it.
Taking this medicine with food can reduce the amount of BACTRIM DS that you will be able to use.
However, if you have allergies to medicines, or if you are allergic to any medicine, this medicine can not be used.
It is important to take this medicine with a full glass of water, preferably on an empty stomach.
Before using this medicine, tell your doctor or pharmacist if you are taking any other medicines, including those you take regularly.
Before you start to take this medicine, tell your doctor if you have kidney disease, or other medical conditions.
Tell your doctor if you are pregnant or breastfeeding. They can advise you on the risks and benefits of using BACTRIM DS.
Tell your doctor if you have any medical conditions, especially: kidney disease, liver disease, heart disease or diabetes.
Taking this medicine with food may reduce the amount of BACTRIM that you will be able to use.
This medicine may impair your thinking or reactions.
Tell your doctor if you are taking any other medicines, especially before or after you have had any surgery.
If you are taking any other medicines, tell your doctor or pharmacist when you start taking any new medicines.
You should keep your mouth and throat dry. Do not swallow sugar pills or gum.
This medicine can cause some side effects.
You should not use this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If you are taking any other medicines, tell your doctor or pharmacist before taking this medicine.
If you are pregnant or breast-feeding, tell your doctor or pharmacist before taking this medicine.
Do not take BACTRIM DS if you are pregnant or breast-feeding.
Do not take this medicine during the first 6 months of pregnancy.
Before taking Bactrim, tell your doctor and pharmacist if you are allergic to Bactrim, any other medications, or any of the ingredients in Bactrim tablets. Ask your pharmacist for a list of the ingredients.
Before using this medication, tell your doctor and pharmacist your medical history; you may have a blood test that shows you have a blood clot (anemia); you may get sickier, nephrotic syndrome (kidney problems such as a condition known as a nephrotic syndrome); you may have kidney problems or lupus (condition causing weight gain); you may develop lupus (relivation of the menstrual periods); your skin may be sensitive to sunlight. This medication may make you dizzy or drowsy or help the fluid in your kidneys to lower blood pressure. Do not drive or do anything that could be dangerous until you know how this drug affects you. Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Your doctor may periodically monitor you or your baby for muscle pain, weakness, breast tenderness, or small changes in breasts (breast enlargement). Do not stop using this medication early without first checking with your doctor; your risk of muscle pain or weakness may increase if you stop use Bactrim. Consult your doctor or pharmacist for more details.
Bactrim may cause your blood sugar to go down (e.g., to normal low or normal range). Check your blood sugar regularly and tell your doctor if you have not been advised to reduce your weight or use an aid; your doctor may advise you to follow-up on this medication to see if you are OK. Some weight loss medications, including Bactrim, may cause blood sugar to increase too low or too high; this effect can be harmful if taken too far. Check with your doctor if you are not sure about any risks or side effects.
It is not known if this medication passes into breast milk.
Tell your doctor if your baby has a skin reaction or if you get sick (fatigue).
Your doctor may advise you to avoid unnecessary or prolonged exposure to sunlight before taking Bactrim. Sunlight can make some things worse (e.g., sunbeds).
Tell your doctor if your baby has ever had any problems with the skin of your arms/legs. This can happen if you have difficulty breathing or your skin has become sensitive to sunlight. This condition is more likely if you are older than 2 months. Ask your doctor or pharmacist about ways to help prevent this from happening to your baby. You may need to use sunscreen or protective clothing during the first few months of pregnancy. During this time, you may get sick (fatigue) from taking Bactrim.
Always use this medication exactly as instructed by your doctor or pharmacist. Do not use it more often or for longer than prescribed. Your doctor may have you take this medication more often or for longer than prescribed.
Your doctor may send you for a blood test (e.g., a urine test), which may show you have a blood clot (anemia). You may get sick (e.g., a feeling of being too tired to make changes), or you may get sick (e.g., weakness, breast pain).
If you get a rash with taking Bactrim, call your doctor immediately or go to the emergency room.
It is not known if Bactrim passes into breast milk.
Your doctor may send you to hospital for a breast cancer screening mammogram (e.g., a X-ray) to check your breast tissue. Your doctor may recommend that you keep using this medication until you are sure it is all right. You may need to use a different form of birth control if you need to avoid getting pregnant while taking this medication.
Your doctor may remind you not to take Bactrim with food. Do not take this medication with dairy products (e.g., milk or calcium).
You may feel sleepy or tired after taking this medication.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store at room temperature away from moisture, heat, and light.
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Bactrim is used to treat:
Please note that we are not responsible for any adverse effects of bactrim which may occur from taking this medication.
If you have any questions about this, or for any other questions to our sales team, please contact us at:
Bactrim is an antibiotic. When taken in conjunction with an appropriate amount of medicine, it may treat a variety of infections. It can also be used to treat:
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